Antibody catalysis of enantio- and diastereo-selective aldol reactions
AssigneeThe Scripps Research Institute
InventorsCarlos F. Barbas, Richard A. Lerner, Guofu Zhong
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Abstract
Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol reaction. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold better than any other antibody catalyst) and enantioselective catalysts for aldol and retro-aldol reactions and exhibit enantio- and diastereo-selectivities opposite that of antibody 38C2.
Claims6
A hybridoma having ATCC accession number PTA-1015 which is capable of expressing antibody 85A2.
A hybridoma having ATCC accession number PTA-1014 which is capable of expressing antibody 85C7.
A hybridoma having ATCC accession number PTA-1017 which is capable of expressing antibody 92F9.
A hybridoma having ATCC accession number PTA-1018 which is capable of expressing antibody 84G11.
A hybridoma having ATCC accession number PTA-1019 which is capable of expressing antibody 84H9.
A hybridoma having ATCC accession number PTA-1016 which is capable of expressing antibody 90G8.
Dependencies are inferred from the claim text.