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US 6,309,874 B1Granted
Selection marker
AssigneeKarolinska Innovations AB
InventorRoger Belusa
Life of this patent
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Abstract
The present invention relates to a new selection marker, namely a mutated (Na,K)-ATPase comprising the amino acid sequence: IFIIANIPXPXGTVTIXXID wherein X is chosen from the group of cysteine, leucine, glycine, alanine, valine, isoleucine, and where at least one X is cysteine.
Claims7
A nucleic acid sequence encoding an oubain-resistant (Na, K)-ATPase comprising SEQ ID NO:
- 9 wherein Xaa at position 17 is Leu, Xaa at position 18 is Cys, and Xaa at at least one of positions 9 and 11 is Cys.
Dependencies are inferred from the claim text.