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AssigneesThe Trustees of Columbia University in the City of New York, Sloan-Kettering Institute for Cancer Research
InventorsRaju S. K. Chaganti, Vadim Dyomin, Riccardo Dalla-Favera
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This invention provides an isolated nucleic acid which encodes bcl-8. This invention also provides an oligonucleotide of at least 15 nucleotides capable of specifically hybridizing with a sequence of nucleotides within a nucleic acid which encodes bcl-8. Further, this invention provides an agent capable of blocking the expression of BCL-8. This invention also provides various methods of determining whether a subject is afflicted with diffuse large cell lymphoma. This invention further provides a method of determining whether a subject has a predisposition for diffuse large cell lymphoma. This invention further provides various methods of treating a subject afflicted with diffuse large cell lymphoma. This invention also provides various methods of preventing diffuse large cell lymphoma in a subject. This invention also provides pharmaceutical compositions for treating and/or preventing diffuse large cell lymphoma.
An isolated nucleic acid which encodes a protein having the amino acid sequence set forth in FIG. 9 (SEQ ID NO:4).
The bacterial cell designated BCL8-P132 and deposited under ATCC Accession No. 98437.
Dependencies are inferred from the claim text.