Family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs
AssigneeCentre National de la Recherche (CNRS)
InventorsFabrice Duprat, Florian Lesage, Michel Fink, Michel Lazdunski
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Abstract
This invention relates to a new member of a recently recognized TWIK potassium+channel family, herein identified as TASK, for TWIK-related acid-sensitive K+ channel. This is the first cloned mammalian channel that produces K+ currents that possesses all the characteristics of background conductances. The invention also relates to various constructs including the TASK or related human potassium channel family, and their uses.
Claims13
An isolated and purified nucleic acid molecule coding for a protein capable of forming a potassium (K+) ion channel, comprising two P domains and three or four transmembrane segments.
Dependencies are inferred from the claim text.