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AssigneeThe Rockfeller University
InventorsJeffrey M. Friedman, Yiying Zhang, Ricardo Proenca
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The present invention relates generally to the control of body weight of animals including mammals and humans, and more particularly to materials identified herein as modulators of body weight, and to diagnostic and therapeutic uses of such modulators. In its broadest aspect, the present invention relates to nucleotide sequences corresponding to the murine and human OB gene, and two isoforms thereof, and proteins expressed by such nucleotides or degenerate variations thereof, that demonstrate the ability to participate in the control of mammalian body weight and that have been postulated to play a critical role in the regulation of body weight and adiposity. The present invention further provides nucleic acid molecules for use as molecular probes or as primers for polymerase chain reaction (PCR) amplification. In further aspects, the present invention provides cloning vectors and mammalian expression vectors comprising the nucleic acid molecules of the invention. The invention further relates to host cells transfected or transformed with an appropriate expression vector and to their use in the preparation of the modulators of the invention. Also provided are antibodies to the OB polypeptide. Moreover, a method for modulating body weight of a mammal is provided.
An isolated nucleic acid encoding an analog of an OB polypeptide, capable of modulating body weight, comprising amino acids 22-167 of SEQ ID NOS:
An isolated nucleic acid encoding an analog of an OB polypeptide, capable of modulating body weight, comprising amino acids 22-167 of SEQ ID NO:
An isolated nucleic acid encoding an analog of an OB polypeptide, capable of modulating body weight, comprising amino acids 22-167 of SEQ ID NOS:
An isolated nucleic acid encoding an OB polypeptide comprising amino acids 22-167 of SEQ ID Nos. 2 or 4 or amino acids 22-166 of SEQ ID Nos. 5 or 6 and capable of modulating body weight said OB polypeptide having an N-terminal amino acid sequence selected from the group consisting of:
An isolated nucleic acid encoding an analog of an OB polypeptide, capable of modulating body weight, comprising amino acids 22-167 of SEQ ID NOS:
An isolated nucleic acid encoding an analog of an OB polypeptide comprising an amino acid sequence of SEQ ID NOS:
An isolated nucleic acid encoding an analog of an OB polypeptide, capable of modulating body weight, comprising amino acids 22-166 of SEQ ID NOS:
An isolated nucleic acid encoding an analog of an OB polypeptide, capable of modulating body weight, comprising amino acids 22-166 of SEQ ID NO:
An isolated nucleic acid encoding an analog of an OB polypeptide, capable of modulating body weight, comprising amino acids 22-166 of SEQ ID NOS:
An isolated nucleic acid encoding an analog of an OB polypeptide comprising an amino acid sequence of SEQ ID NOS:
An isolated nucleic acid encoding an analog of an OB polypeptide, capable of modulating body weight, comprising amino acids 22-166 of SEQ ID NOS:
Dependencies are inferred from the claim text.