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US 6,309,848 B1Granted
Human xenografts for microbicide testing and anatomical modeling
AssigneeThe Penn State Research Foundation
InventorsMary K. Howett, John W. Kreider
Life of this patent
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Abstract
A method for screening candidate antimicrobial compounds is described that utilizes a human vaginal xenograft engrafted in a non-human host. The method may be performed by using pathogen inoculated human vaginal xenografts in order to screen a wide range of candidate antimicrobials administered topically or systemically.
Claims15
A method for screening compounds, comprising:
- a) providing:
- i) an immunocompromised non-human host;
- ii) a human vaginal graft comprising a lumen;
- iii) a candidate compound;
- and iv) a pathogen;
- b) engrafting said vaginal graft within said host to create an engrafted vaginal xenograft comprising a lumen;
- c) introducing said compound systemically into said non-human host;
- d) inoculating said engrafted vaginal xenograft with said pathogen;
- and
- e) testing said engrafted vaginal xenograft for the presence of pathogen.
7 more elements
A method for screening compounds, comprising:
- a) providing:
- i) an immunocompromised non-human host;
- ii) a human vaginal graft comprising a lumen;
- iii) a candidate compound;
- and iv) a pathogen;
- b) engrafting said vaginal graft within said host to create an engrafted vaginal xenograft comprising a lumen;
- c) inoculating said engrafted vaginal xenograft with said pathogen;
- d) introducing said compound systemically into said non-human host;
- and
- e) testing said engrafted vaginal xenograft for the presence of pathogen.
7 more elements
Dependencies are inferred from the claim text.