Back to results
US 6,309,847 B1Granted
Method for detecting or monitoring the effectiveness of treatment of T cell mediated diseases
AssigneeYeda Research and Development Co. Ltd.
InventorsIrun R. Cohen, Dana Elias
Life of this patent
Estimating the term…
Abstract
It has been discovered that treatment of an IDDM model with the p277 auto-antigen in a tolerogenic carrier induces a shift from a TH1 T cell response to a TH2 T cell response. The efficacy of proposed vaccines for any T cell mediated disease can be detected or monitored by measuring for such a TH1→TH2 T cell reponse shift.
Claims3
A method for detecting or monitoring the efficacy of treatment of insulin-dependent diabetes mellitus (IDDM) in an animal by administration of a vaccine comprising a peptide of the 60 kDa heat shock protein auto-antigen in a tolerogenic carrier, the method comprising:
- measuring, prior to treatment, the nature of the cytokine response of T cells from the animal to be treated elicited by in vitro incubation of said T cells with the auto-antigen;
- measuring, after treatment, the nature of the cytokine response of T cells from the treated animal elicited by in vitro incubation of said T cells with the auto-antigen;
- determining whether there has been a shift from a TH1 T cell response prior to treatment to a TH2 T cell response after treatment;
- and
- concluding that there is the probability that the treatment has been effective if a positive finding of such a shift is determined in said determining step.
2 more elements
Dependencies are inferred from the claim text.