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US 6,309,825 B1Granted
Analytical and therapeutic agents
AssigneeUniversity of Leicester
InventorSi ;n Myra Thomas
Life of this patent
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Abstract
According to the present invention there is provided an agent and method of detecting 8-oxoquanine, 8-oxodeoxyguanosine, 8-oxoadenine, and 8-oxodeoxyadenosine.
Claims14
A method for detecting nucleic acid base damage comprising the steps of:
- a) reacting a nucleic acid base-containing sample with an molecule comprising a molecule which binds specifically to biotin and to at least one of 8-oxoguanine, 8-oxodeoxyguanosine, 8-oxoadenine and 8-oxodeoxyadenosine;
- b) detecting any binding reaction between the sample and the molecule;
- and
- c) correlating detection of the sample-molecule binding reaction with the existence and quantity of damaged nucleic acid bases.
1 more element
Dependencies are inferred from the claim text.