Collagen-polysaccharide matrix for treatment of bone tumors
AssigneeOrquest, Inc.
InventorsMohammad Heidaran, Robert C. Spiro
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Abstract
A method of treatment for bone tumors comprising administering a matrix comprising collagen, a polysaccharide and a differentiation factor is provided. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent linkages to collagen.
Claims19
A method for the treatment of a bone tumor comprising the steps of administering at a site of desired treatment a matrix comprising:
- a) collagen covalently crosslinked to an exogenous polysaccharide, wherein said polysaccharide is crosslinked to said collagen through oxidized sugar rings on said polysaccharide which form covalent linkages to said collagen;
- and
- b) a differentiation factor.
A composition for the treatment of a bone tumor comprising an effective tumor-growth inhibiting amount of a matrix comprising collagen covalently cross-linked to an exogeneous polysaccharide wherein said polysaccharide is cross-linked to said collagen through oxidized sugar rings on said polysaccharide which forms covalent linkages to said collagen and a differentiation factor.
Dependencies are inferred from the claim text.