Abuse resistant tablets
AssigneeAventis Pharma S.A.
InventorsRichard James Bastin, Bruce Hamilton Lithgow
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Abstract
This invention relates to an abuse resistant tablet containing two or more layers having one or more drugs and one or more gelling agents and its preparation. The drug(s) and gelling agent(s) are in separate layers of the tablet. The multilayer tablet is particularly suitable for the administration of drugs prone to abuse by unauthorized parenteral administration such as analgesics, hypnotics, and anxiolytics.
Claims22
An abuse resistant tablet containing two or more layers comprising (1) a drug and (2) a gelling agent, wherein the gelling agent has a viscosity within the range of about 4,000 cp to about 100,000 cp, wherein the tablet consists essentially of either (i) separate layers one stacked on top of the other in a sandwich arrangement or (ii) a core layer comprising gelling agent enclosed by one or more layers comprising one or more drugs, wherein essentially all the drugs are contained in a separate layer or layers from all gelling agents.
A bilayer tablet in which one layer comprises the drug zopiclone and the other layer comprises a gelling agent.
A process for the preparation of a tablet comprising an active layer comprising a drug and a gelling layer comprising a gelling agent, in which the process comprises the following steps:
- (i) compressing a first layer from a suitable powder;
- and
- (ii) compressing one or more additional layers on top of the first layer or subsequent layers to form a bilayer or multilayer tablet.
A process for the preparation of a tablet comprising an active layer comprising a drug and a gelling layer comprising a gelling agent, in which the process comprises the following steps:
- (i) preparing the gelling layer by compressing a suitable powder;
- and
- (ii) enclosing the gelling layer with one or more active layers by means of a tablet press.
A tablet comprising a gelling layer, which gelling layer comprises a gelling agent, and an active layer, which active layer comprises a drug, wherein the gelling agent does not impart any significant delay in the rate of drug release and wherein essentially no drug is extractable from the tablet when the tablet is contacted over ten minutes with water.
Dependencies are inferred from the claim text.