Treatment of contact lenses with aqueous solution comprising a carbonate salt for enhanced cleaning
AssigneeBausch & Lomb Incorporated
InventorsErning Xia, Lisa C. Simpson, John Denick, Jr.
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Abstract
The present invention provides methods and compositions for cleaning and disinfecting contact lenses, which compositions comprise a carbonate or bicarbonate salt, a non-carbonate buffer system, an antimicrobial agent, and a non-ionic surfactant. Products according to the present invention, especially multi-purpose solutions, provide simultaneous disinfection and cleaning of contact lenses including the prevention or removal of protein and lipid deposits and other debris.
Claims18
A method of disinfecting or cleaning and disinfecting a soft contact lens with a multi-purpose solution or effective multipurpose solution, which method comprises:
- (a) soaking the lens in an ophthalmically safe solution, such that acceptable disinfection of the contact lens is obtained within a minimum recommended soaking period, the solution comprising, in formulation, the following components:
- (i) 0.010 to 1.0 percent by weight of the solution of an alkali metal carbonate or bicarbonate salt;
- (ii) an effective amount of a buffering system comprising one or more non-carbonate buffers which non-carbonate buffers provide a buffering capacity of 0.01 to 0.5 nM of 0.01 N of HCl and 0.01 to 0.3 of 0.01 N of NaOH to change the pH one unit;
- (iii) an effective amount of a non-ionic surfactant;
- (iv) an effective amount of at least one germicide;
- and
- (b) directly placing the treated lens on the eye of the wearer, such that (i) rinsing with a different solution prior to placement on the eye is not generally required, and (ii) no other solution is generally required for daily cleaning of the lens.
An aqueous solution having a pH from about 5 to about 8 for treating contact lenses comprising:
- (a) 0.010 to 1.0 percent by weight of the solution of an alkali metal carbonate or bicarbonate salt;
- (b) an effective amount of a buffering system comprising one or more non-carbonate buffers which non-carbonate buffers provide a buffering capacity of 0.01 to 0.5 mM of 0.01 N of HCl and 0.01 to 0.3 of 0.01 N of NaOH to change the pH one unit;
- (c) an effective amount of a non-ionic surfactant;
- and
- (d) an effective amount of at least one germicide.
An aqueous solution having a pH from about 5 to about 8 for treating contact lenses
- (a) 0.010 to 1.0 percent by weight of the solution of an alkali metal carbonate or bicarbonate salt;
- and
- (c) an effective amount of a non-ionic surfactant;
- (d) an effective amount of at least one biguanide germicide.
- (e) an effective amount of a buffer system comprising one or more buffers selected form the group consisting of phosphate and borate buffers and mixtures thereof, which buffers provide a buffering capacity of 0.01 to 0.5 mM of 0.01 N of HCl and 0.01 to 0.3 of 0.01 N of NaOH to change the pH one unit.
A method of disinfecting or cleaning and disinfecting a soft contact lens with a multi-purpose solution or effective multipurpose solution, which method comprises:
- (a) soaking the lens in an ophthalmically safe solution, such that acceptable disinfection of the contact lens is obtained within a minimum recommended soaking period, the solution comprising, in formulation, the following components:
- (i) 0.010 to 1.0 percent by weight of the solution of an alkali metal carbonate or bicarbonate salt;
- (ii) an effective amount of a buffering system comprising at least one phosphate buffer and at least one borate buffer to provide a buffering capacity of 0.01 to 0.5 mM of 0.01 N of HCl and 0.01 to 0.3 of 0.01 N of NaOH to change the pH one unit;
- (iii) an effective amount of a non-ionic surfactant;
- (iv) an effective amount of alexidine germicide;
- and
- (b) directly placing the treated lens on the eye of the wearer, such that (i) rinsing with a different solution prior to placement on the eye is not generally required, and (ii) no other solution is generally required for daily cleaning of the lens.
Dependencies are inferred from the claim text.