Attenuated Japanese encephalitis virus adapted to Vero cell and a Japanese encephalitis vaccine
AssigneesCheil Jedang Corporation, The United States of America as represented by the Secretary of the Army
InventorsHyun Su Kim, Wang Don Yoo, Soo Ok Kim, Sung Hee Lee, Sang Bum Moon, Sun Pyo Hong, Yong Cheol Shin, Yong Ju Chung, Kenneth H. Eckels, Bruce Innis, Joseph R. Puniak, Leonard N. Binn, Ashok K. Srivastava, Doria R. Dubois
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Abstract
An attenuated Japanese encephalitis virus adapted to Vero cell by passages on Vero cell is disclosed. A Japanese encephalitis vaccine comprising said attenuated virus is also disclosed.
Claims12
An attenuated Japanese encephalitis virus adapted to Vero cell by passages on Vero cell wherein said virus has a multiplicity of more than 1×10(7) PFU/ml in Vero cells and LD50/pfu for young adult mouse is less than 0.000001.
An attenuated Japanese encephalitis virus adapted to Vero cell by passages on Vero cell which is CJ50003.
Dependencies are inferred from the claim text.