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AssigneesHeska Corporation, Board of Regents, The University of Texas System
InventorsRamaswamy Chandrashekar, Kapil Mehta
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The present invention relates to parasitic nematode transglutaminase proteins; to parasitic nematode transglutaminase nucleic acid molecules, including those that encode such transglutaminase proteins; to antibodies raised against such transglutaminase proteins; and to compounds that inhibit parasitic nematode transglutaminase activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic nematodes. This invention also relates to the surprising discovery that parasitic nematode transglutaminase proteins have protein disulfide isomerase activity. Accordingly, this invention relates further to inhibitors of the protein disulfide isomerase activity of said transglutaminases.
An isolated protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO:28, SEQ ID NO:33, SEQ ID NO:47, SEQ ID NO:52, and SEQ ID NO:55.
An isolated protein encoded by a nucleic acid molecule comprising a nucleic acid sequence selected from the group consisting of:
A composition comprising:
A method to identify a compound capable of inhibiting transglutaminase activity, said method comprising (a) contacting an isolated protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO:28, SEQ ID NO:33, SEQ ID NO:47, SEQ ID NO:52, and SEQ ID NO:55 with a putative inhibitory compound under conditions in which, in the absence of said compound, said protein has transglutaminase activity;
A method to identify a compound capable of inhibiting protein disulfide isomerase activity, said method comprising (a) contacting an isolated protein comprising an amino acid sequence selected from the group consisting of SEQ ID NO:28, SEQ ID NO:33, SEQ ID NO:47, SEQ ID NO:52, and SEQ ID NO:55 with a putative inhibitory compound under conditions in which, in the absence of said compound, said protein has protein disulfide isomerase activity;
Dependencies are inferred from the claim text.