IBD-associated microbial antigens and methods of using same
AssigneeThe Regents of the University of California
InventorsJonathan Braun, Christopher Sutton
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Abstract
The present invention provides nucleic acid and amino acid sequence of the novel I-1 and I-2 polypeptides, which are associated with human inflammatory bowel disease (IBD). Methods of diagnosing and treating inflammatory bowel disease using the IBD-associated I-1 and I-2 antigens also are provided.
Claims11
An isolated inflammatory bowel disease associated I-2 polypeptide, comprising at least 60% amino acid identity with SEQ ID NO:
- 2, said polypeptide having differential reactivity with Crohn's disease patient sera as compared to normal sera.
An isolated inflammatory bowel disease associated I-2 polypeptide, comprising the amino acid sequence SEQ ID NO:
- 2.
An isolated immunoreactive fragment of an I-2 polypeptide, comprising at least 8 contiguous amino acids of SEO ID NO:
- 2.
Dependencies are inferred from the claim text.