Peptides which mimic candida carbohydrate epitopes and their use in a vaccine
AssigneeThe Research and Development Institute, Inc.
InventorsJim E. Cutler, Pati M. Glee
Life of this patent
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Abstract
A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans. The composition includes phosphomannan of C. albicans, peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.
Claims16
A vaccine for the treatment of candidiasis comprising a pharmaceutically effective amount of a protective peptide mimitope, wherein the peptide mimitope binds to an antibody that binds to the same epitope as monoclonal antibody B6.1, American Type Culture Collection Accession Number HB11925.
Dependencies are inferred from the claim text.