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US 6,309,634 B1Granted
Methods of treating Parkinson's disease using recombinant adeno-associated vector (rAAV)
AssigneesAvigen, Inc., The Regents of the University of California
InventorsKrys Bankiewicz, Janet Cunningham
Life of this patent
Estimating the term…
Abstract
Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
Claims2
A method for treating Parkinson's disease in a subject, said method comprising:
- (a) providing a preparation comprising recombinant adeno-associated virus (rAAV) virions, wherein said virions are produced in vitro and comprise a nucleic acid sequence encoding aromatic amino acid decarboxylase (AADC);
- and
- (b) delivering the preparation in vivo, to the brain of the subject, wherein said virions transduce cells, and the AADC is expressed by the cells at levels that provide therapentically effective levels of dopamine upon the oral administration of L-dopa.
Dependencies are inferred from the claim text.