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US 6,309,630 B1Granted
Non-steroidal anti-inflammatory ophthalmic suspensions
AssigneeInsite Vision Incorporated
InventorsRajesh Patel, Lyle M. Bowman, Peng Shen
Life of this patent
Estimating the term…
Abstract
Compositions for topical ophthalmic application comprising an aqueous mixture of a non-steroidal anti-inflammatory agent. The compositions are formulated with a pH and concentration of agent chosen to maintain at least some of the therapeutic agent of the formulation in suspension.
Claims23
A composition for topical ophthalmic application comprising:
- an aqueous mixture of a non-steroidal anti-inflammatory agent, said composition being formulated with a pH and concentration of agent which maintains at least a therapeutic amount of the non-steroidal anti-inflammatory agent of the formulation in suspension and a therapeutic amount of the non-steroidal anti-inflammatory agent of the formulation in solution.
A composition for topical treatment of the eye comprising:
- an aqueous suspension of a non-steroidal anti-inflammatory agent, said composition having a pH of about 4.0 to about 6.8, and containing from about 0.1% to about 6.5% by weight based on the total weight of the suspension of a crosslinked carboxyl-containing polymer, and wherein a therapeutic amount of about 10%-99% of said agent is in suspension and a therapeutic amount of said agent is in solution.
A method for treating the eye comprising the step of:
- applying to an eye an amount of an aqueous suspension of diclofenac effective to treat the eye, said composition having a pH of about 5.0 to about 6.8 and a concentration of diclofenac wherein about 70%-99% of said diclofenac is in suspension and the remainder is in solution.
A method for treating eye inflammation comprising:
- topically applying to an eye an aqueous mixture of a non-steroidal anti-inflammatory agent formulated with a pH and concentration of agent which maintains at least a therapeutic amount of the non-steroidal anti-inflammatory agent in suspension and a therapeutic amount of the non-steroidal anti-inflammatory agent of the formulation in solution, whereby the therapeutic amount of the agent in solution has an immediate therapeutic effect, and the therapeutic amount of agent in suspension has a therapeutic effect by release from the suspension over a period of time.
Dependencies are inferred from the claim text.