US 6,307,957 B1Granted

Multispectral imaging and characterization of biological tissue

AssigneeElectro-Optical Sciences, Inc.

InventorsDina Gutkowicz-Krusin, Marek Elbaum, Michael Greenebaum, Adam Jacobs, Alexandru Bogdan

Life of this patent

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Abstract

A light image is conveyed from a biological tissue through a flexible optical system to an image receiver, where it is converted to a form which may be entered into a computer. The computer segments the image by generating a segmentation mask defining the boundary of a region of interest in at least one spectral band, estimates at least one rotationally and translationally invariant statistical measure of coefficient distributions of the multiscale wavelet maxima representations of the digital images in at least one spectral band, characterizes the condition of the tissue based on the estimated values, and outputs the characterization of the condition of the tissue.

Claims15

Dependent claims

A method of characterizing the condition of a region of interest of biological tissue, wherein the absorption and scattering of light in different spectral bands by the region of interest is a function of the condition of the tissue, the method comprising:

illuminating a portion of the tissue including the region of interest by light in at least one spectral band;
conveying an image of the region of interest through an optical system to an image receiver;
imaging a portion of the tissue including the region of interest at the at least one spectral band with the light re-emitted by the portion of the tissue to generate at least one digital image comprising signals whose values are a function of the condition of the region of interest of the tissue;
and
providing the digital images to a processor, wherein the processor:
segments the digital images by generating a segmentation mask defining the boundary of the region of interest from a digital image in any one of the at least one spectral bands;
estimates at least one rotationally and translationally invariant statistical measure of coefficient distributions of the multiscale wavelet maxima representations of the digital image;
characterizes the condition of the tissue based on the estimated values;
and
outputs the characterization of the condition of the tissue.

7 more elements

Dependencies are inferred from the claim text.

Facts

Application: 09/604,645Filed 27 Jun 2000 · continuation in part
Priority: 28 Feb 1997
Granted: 23 Oct 2001
Term ends: Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61B 1/00163
Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g.…:…
A61B 5/0059
Measuring for diagnostic purposes ; Identification of persons: using light, e.g. diagnosis by transillumination, diascopy, fluorescence
A61B 5/0084
Adapted for particular medical purposes: for introduction into the body, e.g. by catheters
A61B 5/442
Skin evaluation, e.g. for skin disorder diagnosis: evaluating skin mechanical properties, e.g. elasticity, hardness, texture, wrinkle assessment

Family

Application60/039,218Us provisional application · filed 28 Feb 1997
Application60/039,407Us provisional application · filed 28 Feb 1997
Application09/031,929Parent of this continuation-in-part · filed 27 Feb 1998
Application09/032,450Parent of this continuation-in-part · filed 27 Feb 1998
US 6,028,749 AParent of this continuation-in-part · filed 27 Mar 2001
US 6,081,612 AParent of this continuation-in-part
US 6,208,749 B1Related patent
US 6,307,957 B1This patent

From the US filing history. Foreign family members aren’t listed.