Method and apparatus for determination of carbon-halogen compounds and applications thereof
AssigneeSan Diego State University
InventorsClay Marcus Sharts, Vladimir Semenovich Gorelik
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Abstract
A method and apparatus for determination of fluoroorganic compounds in liquid, gaseous, or crystalline or amorphous solids is based on the detection of carbon-halogen bonds by laser Raman spectroscopy. The method and apparatus provide a general method for detecting and determination of halooorganic compounds. The method and apparatus are applicable in the pharmaceutical industry, in fluorinated drug research and manufacturing; in the medical and clinical studies of the effects of fluoroorganic compounds; in the environmental and agricultural studies and screening, in the analysis of water, soils and air contaminated with fluoroorganic compounds.
Claims30
A method for directly detecting, in a sample, a compound having a carbon-fluorine bond, comprising:
- (a) irradiating a sample from a non-continuous periodic pulse light source having a wavelength that induces Raman scattered light emissions from carbon-halogen bonds;
- and
- (b) detecting Raman scattered light emitted from the sample, wherein detection of characteristic Raman scattered light is indicative of a carbon-halogen bond in the sample.
Apparatus for Raman spectroscopy, comprising:
- (a) a non-continuous periodic pulse metal-vapor laser;
- (b) a monochomator for visible and ultraviolet light;
- (c) a detector of secondary radiation;
- and
- (d) a pulse recording system.
A method for detecting a fluoroorganic compound having a molecular length, comprising:
- exposing a sample to an excitation light source;
- measuring a frequency of an acoustic mode of the compound;
- measuring a frequency of an optical mode of the compound;
- detecting a shift in frequency of the acoustic frequency and the optical frequency;
- arid
- approximating the molecular length as a function of the shift in frequencies to determine the presence of the fluoroorganic compound.
Dependencies are inferred from the claim text.