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US 6,307,372 B1Granted
Methods for high throughput chemical screening using magnetic resonance imaging
AssigneeGlaxo Wellcome Inc.
InventorsJeffrey H. Sugarman, Joshua M. Star-Lack
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Abstract
A screening method is provided that comprises the steps of performing an assay in which one or more chemicals and/or entities are present in a mixture to produce an outcome. A static magnetic field B0 is applied to the mixture, and one or more RF magnetic pulses are also applied to the mixture. Multiple assays may be conducted simultaneously through the use of magnetic resonance imaging techniques.
Claims43
A screening method comprising:
- performing an assay in which one or more chemicals and/or entities are present in a mixture to produce an outcome;
- applying a static magnetic field (B0) to the mixture;
- applying one or more RF magnetic pulses to the mixture;
- and
- measuring and evaluating resulting FID or echo signals to evaluate the outcome of the assay.
2 more elements
A method of screening comprising:
- combining a test compound with another chemical and/or entity to form a mixture, wherein the test compound causes a detectable nuclear magnetic resonance signal to be produced that is dependent on the amount of interaction of the test compound with the mixture;
- applying a static magnetic field (B0) to the mixture;
- applying one or more RF magnetic pulses to the mixture;
- and
- measuring and evaluating resulting FID or echo signals to obtain information as to whether the test compound is biologically active in the mixture.
2 more elements
A method of screening comprising:
- providing a plurality of plates that each include multiple wells;
- introducing a chemical and/or entity into at least some of the wells of each plate;
- introducing a test compound into wells containing the chemical and/or entity;
- stacking the plates on top of each other;
- and
- inserting the plates into a nuclear magnetic resonance device and screening for any biologically active test compounds.
3 more elements
Dependencies are inferred from the claim text.