Infection of human neural xenografts
OwnerLeon G. Epstein, Manuel Del Cerro +1inventors
InventorsLeon G. Epstein, Manuel Del Cerro, Benjamin M. Blumberg
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Abstract
Immunocompromised or immunosuppressed non-primate chimeric mammalian hosts comprising a neuronal graft in the eye are provided for studying various events associated with humans. Particularly, the chimeric host may have solely human fetal neuronal xenografts or other fetal xenografts with other tissue, where the various tissues may be studied as to their response to a variety of agents, their response to pathogens or other diseased states, or their response to agents for the treatment of the various indications.
Claims20
An immunocompromised murine host having an HIV infected human fetal neural transplant in the eye, wherein said neural implant is vascularized and has an intact blood brain barrier.
An immunocompromised murine chimeric host having a human fetal neural transplant in the eye, wherein said host lacks mature B- and T-cells as a result of a genetic lesion, and wherein said neural implant is vascularized, has an intact blood brain barrier and is capable of being infected with a virus.
A method for determining the effect of an antiviral agent on diseased human neural tissue, said method comprising:
- administering said agent to an immunocompromised murine chimeric host having HIV infected human fetal neural transplant in the eye, wherein said neural implants is vascularized and has an intact blood brain barrier;
- and
- determining the effect of said agent on said diseased neural tissue.
A method for determining the effect of an agent on human neural tissue, said method comprising:
- administering said agent to an immunocompromised murine chimeric host having a human fetal neural transplant in the eye, wherein said host lacks mature B- and T-cells as a result of a genetic lesion, has a second human transplant of tissue other than neural tissue at other than the eye, and wherein said neural implant is vascularized and has an intact blood brain barrier;
- and
- determining the effect of said agent on said neural tissue.
Dependencies are inferred from the claim text.