High purity preparation of fluorinated 1,3-dicarbonyls using BDM (bis-fluroxy difluoromethane)
AssigneeAir Products and Chemicals, Inc.
InventorsWilliam Jack Casteel, Jr., Robert George Syvret, Wade Hampton Bailey, III
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Abstract
A process for providing an α-fluorinated-β-dicarbonyl includes electrophilically fluorinating a β-dicarbonyl with bis-fluoroxydifluoromethane in the presence of an acid to provide the α-monofluorinated-β-dicarbonyl. The acid is preferably hydrofluoric acid. Preferred β-dicarbonyls include methyl-3-oxopentanoate and ethyl-4,4,4-trifluoroacetoacetate. The process can limit radical impurity byproducts to no more than 4% in some cases, and less than 0.5% in other cases. Theoretical yields of 95% α-monofluorinated-β-dicarbonyl are possible in some cases.
Claims19
A process for providing an α-fluorinated-β-dicarbonyl, said process comprising electrophilically fluorinating a β-dicarbonyl with bis-fluoroxydifluoromethane in the presence of an acid to provide said α-fluorinated-β-dicarbonyl.
Dependencies are inferred from the claim text.