Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use

A compound comprising the formula:

• wherein
• A is selected from the group consisting of C═O and CHOH;
• M is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, and heteroaryl;
• R1 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, heterocyclic and heterocyclicalkyl;
• R2 is hydrogen, or R1 and R2 together with the nitrogen atom to which they are attached form a heterocyclic or heteroaryl ring;
• R3 is —(CH2)n—V wherein n is a whole number from 0 to 4 and V is selected from the group consisting of hydrogen, alkyl, substituted alkyl, —OR, —NR12R13, and —SR13, wherein R12 and R13 are each independently hydrogen, allyl, substituted alkyl, alkenyl, aryl, arylalkyl, —C(O)-alkyl, —C(O)-substituted alkyl, —C(O)-aryl, —C(O)-heteroaryl, heteroaryl heterocyclic, heterocyclicalkyl or heteroarylalkyl wherein, in the case of —NR12R13, the nitrogen atom is optionally incorporated into the heteroaryl or heterocyclic ring structure;
• and
• pharmaceutically acceptable salts thereof.