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US 6,307,088 B1Granted
Synthesis of taxol, taxol analogs and their intermediates with variable A-ring side chain structures and compositions thereof
AssigneesNaPro BioTherapeutics, Inc., Bryn Mawr College
InventorsCharles S. Swindell, Nancy Krauss
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Abstract
The present invention concerns alkyl esters of β-amino acid derivatives which are useful in the synthesis of taxol and analogs.
Claims19
A chemical compound useful in the production of taxol, taxol analogues and their intermediates having a formula:
- wherein
- R1=an olefinic group, an aromatic group or PhCH2;
- R2=an alkyl group, an olefinic group, an aromatic group, hydrogen or Ph;
- R3=an alkyl group;
- and
- P1=a hydroxyl protecting group or hydrogen, provided said hydroxyl protecting group is not a hydrogenatable benzyl protecting group.
3 more elements
A chemical compound useful in the production of taxol, taxol analogues and their intermediates having a formula:
- wherein P1 is selected from a group consisting of H and CH2OCH2CCl3.
A chemical compound useful in the production of taxol, taxol analogues and their intermediates having a formula:
- wherein
- R1=an olefinic group, an aromatic group or PhCH2;
- P1=a hydroxyl protecting group or hydrogen, provided said hydroxyl protecting group is not a hydrogenatable benzyl protecting group.
Dependencies are inferred from the claim text.