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US 6,307,075 B2Granted
Therapeutically effective 1α, 25-dihydroxyvitamin D3 analogs
AssigneeThe Regents of the University of California
InventorsAnthony W. Norman, William H. Okamura
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Abstract
Novel analogs of 1α,25-dihydroxyvitamin D3 which are selective agonists for the genomic responses or agonists or antagonists for the rapid cellular responses in a wide array of diseases in which 1α,25-dihydroxyvitamin D3 or its prodrugs are involved. Novel analogs have general formulae represented by compounds of groups I-V. A method for treatment and prevention of diseases connected with the endocrine system.
Claims3
A compound of the formula I
- wherein R1 is methyl;
- wherein C1-C3 are positional isomers α and β in an α-βconfiguration;
- wherein C5-C6 double bond is cis or trans;
- wherein C7-C8 double bond is cis;
- wherein C14 hydrogen is α;
- wherein C16-C17 is a single bond;
- and
- wherein R2 is a substituent I-1
5 more elements
Dependencies are inferred from the claim text.