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US 6,307,064 B1Granted
Process to prepare taxol
AssigneePharmacia & Upjohn Company
InventorsPeter G. M. Wuts, Robert C. Kelly
Life of this patent
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Abstract
The present invention includes processes to prepare commercially important taxols (X) from substituted amino-3-phenyl (2R,3S) isoserinates (II). In addition processes to prepare the substituted amino-3-phenyl (2R,3S) isoserinates (II) as well as its precursor are set forth.
Claims1
Phenylisoserine ester of silylated baccatin III (VII)
- where R6 and R7 are:
- (1) R6 is —H:—H and R7 is α=—H:β-OR7-1 where R7-1 is —Si(R7-2)3 where two of R7-2 are C1 alkyl and the other is —CH(CH3)—CH(CH3)2 and where R10 is:
- (1) α-H:β-O—CO—CH3 or
- (2) α-H:β-O—CO—O—CH2—CCl3;
- where R11, R12 and R13 are:
- (1) R11 and R12 are taken together to form a second bond between the carbon atoms to which they are attached and R13 is —H.
3 more elements
Dependencies are inferred from the claim text.