US 6,307,054 B1 · Process for preparing 2,4- dihydroxypyridine and 2,4- dihydroxy-3-nitropyridine

Abstract

The present invention is directed to a process for preparing 2,4-dihydroxy-pyridine comprising heating a compound of the formula A wherein R is H, alkyl or aralkyl and phosphoric acid where the ratio of phosphoric acid to water is not less than about 27 to 1 weight %. The invention is also directed to a process for preparing 2,4-dihydroxy-3-nitropyridine comprising reacting 2,4-dihydroxypyridine with nitric acid. The processes of the present invention prepare intermediates which are useful in preparing compounds which are useful for treating cardiovascular disease marked by hypertension or myocardial ischemia, ameliorating ischenic injury or myocardial infarct size, or treating hyperlipidemia or hypercholesterolemia.

Claims4

Dependent claims

A process for preparing 2,4-dihydroxypyridine comprising heating a compound of the formula A

wherein R is H, alkyl or aralkyl and phosphoric acid where the ratio of phosphoric acid to water is not less than about 27 to 1 weight %.

Dependencies are inferred from the claim text.

Facts

Application

09/108,622Filed 1 Jul 1998 · continuation

Priority

2 Jan 1996

Granted

23 Oct 2001

Term ends

Not estimatedThe source records don’t support an estimate.

Classification4 codes

C07D 213/80
Acids; Esters: in position 3
C07D 213/61
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
C07D 473/00
Heterocyclic compounds containing purine ring systems
C07D
Heterocyclic compounds

Process for preparing 2,4- dihydroxypyridine and 2,4- dihydroxy-3-nitropyridine

Life of this patent

Process for preparing 2,4- dihydroxypyridine and 2,4- dihydroxy-3-nitropyridine

Life of this patent

Abstract

Claims4