Bradykinin B1 receptor antibodies
AssigneeMerck & Co., Inc.
InventorsDavid L. Linemeyer, John W. Hess, Joseph A. Borkowski, Kathleen K. Bierilo, John G. Menke
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Abstract
DNAs encoding bradykinin B1 receptors from mammalian cells have been cloned and characterized. The recombinant receptor is capable of forming receptors which bind desArg10 kallidin and other B1-specific ligands. The DNA has been expressed in recombinant host cells which produce active recombinant protein. In addition, the recombinant host cells are utilized to establish a method for identifying modulators of the receptor activity, and receptor modulators are identified.
Claims8
A monospecific antibody immunologically reactive with a bradykinin B1 receptor, the bradykinin B1 receptor comprising the amino acid sequence as set forth in SEQ ID NO:2, or portion thereof.
A monospecific antibody immunologically reactive with a bradykinin B1 receptor, the bradykinin B1 receptor consisting of the amino acid sequence as set forth in SEQ ID NO:2, or portion thereof.
A polyclonal antibody preparation which is immunologically reactive with a bradykinin B1 receptor, the bradykinin B1 receptor comprising the amino acid sequence as set forth in SEQ ID NO:2, or portion thereof.
A polyclonal antibody preparation which is immunologically reactive with a bradykinin B1 receptor, the bradykinin B1 receptor consists of the amino acid sequence as set forth in SEQ ID NO:2, or portion thereof.
Dependencies are inferred from the claim text.