VCAM fusion proteins and DNA coding therefor
AssigneeBiogen, Inc.
InventorsCatherine A. Hession, Roy R. Lobb, Susan E. Goelz, Laurelee Osborn, Christopher D. Benjamin, Margaret D. Rosa
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Abstract
VCAM fusion proteins capable of binding to VLA4, and DNA molecules coding on these fusions.
Claims7
A recombinant DNA molecule encoding an VCAM immunoglobulin fusion protein consisting of the DNA of SEQ. ID. NO:3 or SEQ. ID. NO:4 encoding VCAM1, VCAM1b or a fragment thereof that binds of VLA4 and a DNA sequence encoding the constant region of an immunoglobulin molecule.
A recombinant DNA molecule encoding a VCAM/immunoglobulin fusion protein, wherein the VCAM of the fusion protein is encoded by a DNA molecule selected from the group consisting of the DNA sequence found in plasmid AM pCDM8 clone 41, ATCC Number 66784;
- and the DNA sequence found in plasmid 1E11 pCDM8, ATCC Number 68777.
A recombinant DNA molecule encoding a soluble VCAM fusion protein, wherein the protein comprisis amino acids selected from the group consisting of:
- (a) amino acids 1-217 of FIG. 2 (SEQ ID NO:5)
- (b) amino acids 1-317 of FIG. 3 (SEQ ID NO:6)
- (c) amino acids 1-606 of FIG. 2 (SEQ ID NO:5)
- (d) amino acids 1-698 of FIG. 3 (SEQ ID NO:6).
Dependencies are inferred from the claim text.