Method and composition for enhancing transport across biological membranes
AssigneeThe Board of Trustees of the Leland Stanford Jr. University
InventorsJonathan B. Rothbard, Paul A. Wender
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Abstract
Methods and compositions for transporting drugs and macromolecules across biological membranes are disclosed. In one embodiment, the invention includes a method for enhancing transport of a selected compound across a biological membrane, wherein a biological membrane is contacted with a conjugate containing a biologically active agent that is covalently attached to a transport polymer. In one embodiment, the polymer consists of from 6 to 25 subunits, at least 50% of which contain a guanidino or amidino sidechain moiety. The polymer is effective to impart to the attached agent a rate of trans-membrane transport across a biological membrane that is greater than the rate of trans-membrane transport of the agent in nonconjugated form.
Claims15
A composition for delivering paclitaxel across a biological membrane, comprising:
- a conjugate containing paclitaxel covalently attached via a linker that is cleavable in vivo to a transport peptide, wherein said peptide consists of from 6 to 25 amino acid residues, at least 50% of which contain a guanidino or amidino sidechain moiety, and contains at least 6 contiguous guanidino and/or amidino sidechain moieties,
- whereby said attached transport peptide is capable of delivering said paclitaxel across a biological membrane.
Dependencies are inferred from the claim text.