Progestin therapy for maintaining amenorrhea
AssigneeColumbia Laboratories, Inc.
InventorsDominique de Ziegler, William J. Bologna, Howard L. Levine
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Abstract
The present invention teaches that daily, cyclical vaginal delivery of progestin may be used to provide regular, predictable withdrawal bleeding during hormone replacement therapy. The present invention also teaches that constant administration of progestin in a water-insoluble, water-swellable cross-linked polycarboxylic acid polymer may be used to maintain amenorrhea. Either regimen is accompanied by a significant decrease in adverse side effects.
Claims11
A method of maintaining amenorrhea in a woman undergoing constant progestin administration comprising constant vaginal administration of progestin via a drug delivery system in an amount sufficient to cause endometrial atrophy within the first month of administration and to maintain endometrial atrophy without causing the side effects encountered with progestin administration:
- wherein the drug delivery system comprises a water-soluble, water-swellable cross-linked polycarboxylic acid polymer.
Dependencies are inferred from the claim text.