Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases

A pharmaceutical composition comprising compound 4

• or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.

Method for treating a patient having a neurological disease or disorder selected from the group consisting of global and focal ischemic and hemorrhagic stroke, head trauma, spinal cord injury, hypoxia-induced nerve cell damage, nerve cell damage caused by cardiac arrest or neonatal distress, epilepsy, anxiety, diabetes mellitus, multiple sclerosis, phantom limb pain, causalgia, neuralgias, herpes zoster, spinal cord lesions, hyper algesia, allodynia, Alzheimer's Disease, Huntington's disease, and Parkinson's disease, wherein said treatment comprises administering a pharmaceutical composition comprising compound 4

• or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.

Method for treating a patient having a neurological disease or disorder selected from the group consisting of global and focal ischemic and hemorrhagic stroke, head trauma, spinal cord injury, hypoxia-induced nerve cell damage, nerve cell damage caused by cardiac arrest or neonatal distress, epilepsy, anxiety, diabetes mellitus, multiple sclerosis, phantom limb pain, causalgia, neuralgias, herpes zoster, spinal cord lesions, hyper algesia, allodynia, Alzheimer's Disease, Huntington's disease, and Parkinson's disease, wherein said treatment comprises administering a pharmaceutical composition comprising a compound selected from the group consisting of

• or a pharmaceutically acceptable salt thereof.

A compound selected from the group consisting of

• or a pharmaceutically acceptable salt thereof.

A compound selected from the group consisting of

• or a pharmaceutically acceptable salt thereof.

A pharmaceutical composition comprising compound 5

• or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.

Method for treating a patient having a neurological disease or disorder selected from the group consisting of global and focal ischemic and hemorrhagic stroke, head trauma, spinal cord injury, hypoxia-induced nerve cell damage, nerve cell damage caused by cardiac arrest or neonatal distress, epilepsy, anxiety, diabetes mellitus, multiple sclerosis, phantom limb pain, causalgia, neuralgias, herpes zoster, spinal cord lesions, hyper algesia, allodynia, Alzheimer's Disease, Huntington's disease, and Parkinson's disease, wherein said treatment comprises administering a pharmaceutical composition comprising

Method for treating a patient having a neurological disease or disorder selected from the group consisting of global and focal ischemic and hemorrhagic stroke, head trauma, spinal cord injury, hypoxia-induced nerve cell damage, nerve cell damage caused by cardiac arrest or neonatal distress, epilepsy, anxiety, diabetes mellitus, multiple sclerosis, phantom limb pain, causalgia, neuralgias, herpes zoster, spinal cord lesions, hyper algesia, allodynia, Alzheimer's Disease, Huntington's disease, and Parkinson's disease, wherein said treatment comprises administering a pharmaceutical composition comprising a compound selected from the group consisting of

• or a pharmaceutically acceptable salt thereof.