Substituted oxygen alicyclic compounds, including methods for synthesis thereof

A compound of the following Formula III:

• wherein Ar is optionally substituted carbocyclic aryl or optionally substituted heteroaryl;
• Z is a chemical bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted alkynylene, optionally substituted heteroalkylene, optionally substituted heteroalkenylene, optionally substituted heteroalkylene, or a hetero atom;
• each R1 is independently hydrogen or a non-hydrogen substituent;
• q is an integer of from 0 to 9;
• and pharmaceutically salts thereof.

A compound of the following Formula IV:

• wherein Ar is optionally substituted carbocyclic aryl or optionally substituted heteroaryl;
• Z is a chemical bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted alkynylene, optionally substituted heteroalkylene, optionally substituted heteroalkenylene, optionally substituted heteroalkenylene, or a hetero atom;
• each R1 is independently hydrogen or a non-hydrogen substituent;
• r is an integer of from 0 to 11;
• and pharmaceutically acceptable salts thereof.

A compound of the following Formula V:

• wherein Ar is optionally substituted carbocyclic aryl or optionally substituted heteroaryl;
• Z is a chemical bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted alkynylene, optionally substituted heteroalkylene, optionally substituted heteroalkenylene, optionally substituted heteroalkenylene, or a hetero atom;
• each R1 is independently hydrogen or a non-hydrogen substituent;
• s is an integer of from 0 to 9;
• and pharmaceutically salts thereof.