Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors

A method for analgesic, antiinflammatory, or antipyretic treatment in a warm blooded vertebrate animal, comprising administering to the animal a treatment-effective amount sufficient to create an analgesic, antiinflammatory, or antipyretic effect of a compound of the formula

• where:
• R=C1 to C6 alkyl, C1 to C6 branched alkyl, C4 to C8 cycloalkyl, C1 to C6 hydroxyalkyl, branched C1 to C6 hydroxyalkyl, hydroxy substituted C4 to C8 aryl, primary, secondary or tertiary C1 to C6 alkylamino, primary, secondary or tertiary branched C1 to C6 alkylamino, primary, secondary or tertiary C4 to C8 arylamino, C1 to C6 alkylcarboxylic acid, branched C1 to C6 alkylcarboxylic acid, C1 to C6 alkylester, branched C1 to C6 alkylester, C4 to C8 aryl, C4 to C8 arylcarboxylic acid, C4 to C8 arylester, C4 to C8 aryl substituted C1 to C6 alkyl, C4 to C8 heterocyclic alkyl or aryl with O, N or S in the ring, alkyl-substituted or aryl-substituted C4 to C8 heterocyclic alkyl or aryl with O, N or S in the ring, or halo-substituted versions of the afore mentioned moieties defining R, where halo is chloro, bromo, fluoro or iodo,
• R=C1 to C6 alkyl, C1 to C6 branched alkyl, C4 to C8 cycloalkyl, C4 to C8 aryl, C4 to C8 aryl-substituted C1 to C6 alkyl, C1 to C6 alkoxy, C1 to C6 branched alkoxy, C4 to C8 aryloxy, or halo-substituted versions of the afore mentioned moieties defining R1, or R1 is halo, where halo is chloro, fluoro, bromo, or iodo,
• R2=hydrogen, C1 to C6 alkyl or C1 to C6 branched alkyl,
• n=1, 2, 3, or 4, and
• when R3=halobenzyl, then X=NH or N—R4, where R4=C1 to C6 alkyl or C1 to C6 branched alkyl,
• when R3=halobenzoyl, then X=O,
• and the compound possesses selectivity for inhibition of cyclooxygenase-2, where selectivity is at least 1015 for the ratio of IC50 for cyclooxygenase-1 divided by IC50 for cyclooxygenase-2.