Activated iododerivatives for the treatment of cancer and AIDS
OwnerRandall W. Yatscoff, Robert T. Foster +1inventors
InventorsRandall W. Yatscoff, Robert T. Foster, Selvaraj Naicker
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Abstract
A series of activated iodo-benzamide derivatives are described as antineoplastic and antiviral drug compounds. The compounds generally possess a chelating group, a thiol trapping group and an activating group. The presumptive mechanism of action in preventing cancer cell and virus replication is through inhibition of the binding of transcription factors to zinc finger binding domains. The compounds are effective in inhibiting growth of a variety of human and animal tumor and leukemia cell lines at low concentrations.
Claims4
A compound represented by the formula:
- wherein:
- R4 is:
- (i) —CH2CH═CH2,
- (ii) —CH2CH═CH,
- (iii) —NHCH═CH2,
- (iv) —NHCH═CH,
- (v) OH,
- (vi)
- (viii) —(CH2)aN(R5)(R6) wherein a=1 or 2 and R5 and R6 are H or lower alkyl,
- (ix)
- where R7 is H or CF3,
- (x)
- wherein X is H, —NO2, —CO2CH3 or CH3;
- and R8 is H or CH3,
- (xii)
- (xiii)
A method for treating a neoplastic disease selected from the group consisting of colon adenocarcinoma, myeloma, breast adenocarcinoma, melanoma, lung carcinoma, ovarian adenocarcinoma and leukemia comprising administering to a patient in need thereof, an effective amount of a compound:
- wherein Z is:
Dependencies are inferred from the claim text.