Pyrrolo[3,4-d]pyrimidinone derivatives and their use as medicaments

A method of treating asthma in a patient in need of such treatment, said method comprising the step of administering to said patient a therapeutically effective amount of a compound of formula (I)

• wherein—
• W represents —CH2— or a bond;
• Q represents an aryl group Ar1 or Ar2;
• in the case where W represents —CH2—, Q represents Ar1 wherein Ar1 represents naphthyl, phenyl, quinolyl, isoquinolyl, indolyl, benzofuranyl or benzothienyl;
• in the case where W represents a bond, Q represents an aryl group Ar2 wherein Ar2 represents acenaphthenyl, fluorenyl or indanyl;
• wherein the ring systems which Ar1 and Ar2 represent may all be optionally substituted by one or more substituents selected from C1-4 alkyl, C1-4 alkoxy, halogen, or trifluoromethyl;
• R10 represents X—(A)p—Y;
• X represents S(O)n, C≡C, (CH2)2, CH═CH or CH2CH═CH;
• n represents 0, 1 or 2;
• A represents C1-6 alkylene;
• p is 0 or 1;
• Y represents CN, OR11, CO2R12, CONR13R14, NR15R16, NHSO2R17, NHCOR18 or an optionally substituted aryl or heteroaryl group, provided that when X represents S(O)n and Y is other than an optionally substituted aryl or heteroaryl group, then p is 1 and also provided that when X represents S(O)n, p is 1 and Y represents OH, then n is not 0;
• R13 and R14 independently represent H, C1-5 alkyl or phenyl, which latter group may be substituted by one or more substituents selected from C1-4 alkyl, C1-4 alkoxy, halogen, or CO2R21;
• and R1, R2, R11, R12, R15, R16, R17, R18 and R21 independently represent H or C1-5 alkyl;
• or a pharmaceutically acceptable derivative thereof.