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US 6,306,854 B1Granted
Chemical compounds
AssigneeGlaxoSmithKline LLC
InventorsPeter Jonathan Brown, James Mood Chapman, Jr., Jeffrey Alan Oplinger, Ludwig William Stuart, Timothy Mark Willson, Zhengdong Wu
Life of this patent
Estimating the term…
Abstract
Novel compounds of Formula (1) and esters, salts, and physiologically functional derivatives thereof are disclosed. Methods for preparing and using the compounds are also disclosed. Many of these compounds are selective activators of PPAR alpha. The compounds are particularly useful for treating obesity.
Claims9
A compound of Formula (1), or a salt thereof
- wherein m is from 0 to 20, R6 is selected from the group consisting of hydrogen and
- and R8 is selected from the group consisting of
- where y is 0, 1, or 2, each alk is independently hydrogen or alkyl group containing 1 to 6 carbon atoms, each R group is independently hydrogen, halogen, cyano, —NO2, phenyl, straight or branched alkyl or fluoroalkyl containing 1 to 6 carbon atoms and which can contain hetero atoms such as nitrogen, oxygen, or sulfur and which can contain functional groups such as ketone or ester, cycloalkyl containing 3 to 7 carbon atoms, or two R groups bonded to adjacent carbon atoms can, together with the carbon atoms to which they are bonded, form an aliphatic or aromatic ring or multi ring system, and where each depicted ring has no more than 3 alk groups.
Dependencies are inferred from the claim text.