Method for treating demyelinating disease
AssigneeThe Trustees of Columbia University in the City of New York
InventorVincent P. Butler, Jr.
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Abstract
The present invention provides a method for treating a demyelinating disease in a subject which includes administering to the subject a therapeutically effective amount of a high affinity neuromodulatory Na,K-ATPase so as to treat the demyelinating disease.
Claims15
A method for treating a demyelinating disease in a subject which comprises administering to the subject a therapeutically effective amount of a cardiac genin so as to treat the demyelinating disease, wherein the cardiac genin is a compound having the structure:
- wherein
- the compound is (+) or (−);
- R1 is 2-pyrone or 2-furanone;
- R2 and R7 are each independently H, OH or OCOCH3;
- R3 is H;
- R4 is OH;
- R5 is H, or OH;
- R6 is H, or OH;
- R8, R9 and R11 are each independently H or OH;
- R10 is HCO3, CH3, CHO, or CH2OH;
- R12 is H, OH or ═O;
- or a pharmaceutically acceptable salt or ester thereof.
A method for treating a demyelinating disease in a subject which comprises administering to the subject a therapeutically effective amount of a cardiac genin so as to treat the demyelinating disease, wherein the cardiac genin has the structure:
- wherein R1 is H or OH or a pharmaceutically acceptable salt or ester thereof.
Dependencies are inferred from the claim text.