Protected forms of a combination of pharmacologically active agents and uses therefor
AssigneeMedinox, Inc.
InventorsChing-San Lai, Tingmin Wang
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Abstract
In accordance with the present invention, there are provided conjugates of a combination of pharmacologically active agents (e.g., NSAIDs and selective COX-2 inhibitors). Invention conjugates provide a new class of pharmacologically active agents (e.g., anti-inflammatory agents) which provide the therapeutic benefits of both NSAIDs and selective COX-2 inhibitors, while causing a much lower incidence of side-effects then are typically observed with such agents due to the protective effects imparted by modifying the pharmacologically active agents as described herein.
Claims20
A compound having the structure:
- X-L-Y
- wherein:
- X=a non-steroidal anti-inflammatory drug (NSAID),
- L=an optional linker/spacer, and
- Y=a selective COX-2 inhibitor.
In the administration of a non-steroidal anti-inflammatory drug (NSAID) and/or a selective COX-2 inhibitor to a subject for the treatment of a pathological condition, the improvement comprising covalently attaching said NSAID to said selective COX-2 inhibitor prior to administration thereof to said subject.
In the treatment of a subject suffering from a pathological condition by administration thereto of a non-steroidal anti-inflammatory drug (NSAID) and/or a selective COX-2 inhibitor, the improvement comprising covalently attaching said NSAID to said selective COX-2 inhibitor prior to administration thereof to said subject.
A method for the treatment of a subject afflicted with a pathological condition, said method comprising administering to said subject an effective amount of a non-steroidal anti-inflammatory drug (NSAID),
- wherein said NSAID is effective for treatment of said condition, and
- wherein said NSAID has been modified by the covalent attachment thereto of a selective COX-2 inhibitor.
A method for the preparation of a protected form of a non-steroidal anti-inflammatory drug (NSAID), said method comprising covalently attaching a selective COX-2 inhibitor to said NSAID.
A method for reducing the side effects induced by administration of a non-steroidal anti-inflammatory drug (NSAID) to a subject, said method comprising covalently attaching a selective COX-2 inhibitor to said NSAID prior to administration to said subject.
A method for enhancing the effectiveness of a non-steroidal anti-inflammatory drug (NSAID), said method comprising covalently attaching a selective COX-2 inhibitor to said NSAID.
A method for the treatment of a subject afflicted with a pathological condition, said method comprising administering to said subject an effective amount of a selective COX-2 inhibitor,
- wherein said selective COX-2 inhibitor is effective for treatment of said condition, and
- wherein said selective COX-2 inhibitor has been modified by the covalent attachment thereto of a non-steroidal anti-inflammatory drug (NSAID).
A method for the preparation of a protected form of a selective COX-2 inhibitor, said method comprising covalently attaching a non-steroidal anti-inflammatory drug (NSAID) to said selective COX-2 inhibitor.
A method for reducing the side effects induced by administration of a selective COX-2 inhibitor to a subject, said method comprising covalently attaching a non-steroidal anti-inflammatory drug (NSAID) to said selective COX-2 inhibitor prior to administration to said subject.
A method for enhancing the effectiveness of a selective COX-2 inhibitor, said method comprising covalently attaching a non-steroidal anti-inflammatory drug (NSAID) to said selective COX-2 inhibitor.
Dependencies are inferred from the claim text.