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AssigneeSichuan Research Institute of Nature Drugs
InventorsShiqi Peng, Chao Wang, Ming Zhao, Xingwei Li, Yancheng Wu, Taigang Mo
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The present invention relates to a new kind of heavy metal chelating agents and a preparation process and uses thereof. The said heavy metal chelating agents are expressed in α-[D(+)glucose-1-yl-amino]-β3-mercapto-(S)-propanoic acid (abbreviated to NGP,I) and/or N,N′-di[D(+)glucose-1-yl]-L-cystine (abbreviated to NGCD,II). In the process of preparation, glucose and cysteine are reacted with a base, with a reducing agent, and the obtained products are acidified to give NGP,I, which can be used in and/or as drugs, health foods and food additives for accelerating the excretion of heavy metals including Pb, Cd, Hg, Al, Sb, As, etc. The structural feature of the compounds of the present invention is that they contain glucose and cysteirie in their molecules. Compared with the heavy metal-excreting drugs of prior art, the compounds of the present invention have four advantages, namely suitability for oral administration, high ability to accelerate the excretion of heavy metals, high selectivity and less toxicity.
A heavy metal chelating agent selected from the group consisting of α-[D(+)glucose-1-yl-amino]-β-mercapto-(S)-propanoic acid(NGP,I)and N,N′-di[D(+)glucose-1-yl-amino]-L-cystine(NGCD,II).
A process for preparing a heavy metal chelating agent, characterized in that glucose and cysteine are reacted with a base and with a reducing agent, and then acidified further to yield NGP,I.
Dependencies are inferred from the claim text.