Biocidal chitosan derivatives
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsWilliam H. Daly, Melissa A. Manuszak-Guerrini
Life of this patent
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Abstract
3-trimethylammonium-2-hydroxypropyl-N-chitosan (CHI-Q188) and related chitosan derivatives exhibit antimicrobial activity at concentrations as low as 10-20 μg/mL, an order of magnitude lower than the concentrations at which any previous chitosan derivative has been reported to exhibit antimicrobial activity. These compounds may be used as preservatives in cosmetic formulations, and as antimicrobial pharmaceutical agents.
Claims6
A process for killing bacteria, comprising administering to the bacteria an effective amount of the compound
- wherein R1 denotes —H, —COCH3, or —CH2—CHOH—CH2—N+(CH3)2R2X−, wherein the proportion of R1s that are —CH2—CHOH—CH2—N+(CH3)2R2X− is between about 10% and 100%;
- wherein R2 denotes a substituted or unsubstituted alkyl or aryl group from C1 to C2;
- wherein X− denotes an anion;
- and wherein the degree of polymerization n is 5 or greater.
Dependencies are inferred from the claim text.