Acyl deoxyribonucleoside derivatives and uses thereof
AssigneePro-Neuron, Inc.
InventorsReid Warren von Borstel, Michael Kevin Bamat
Life of this patent
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Abstract
The invention relates to compositions comprising acyl derivatives of 2′-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced biological damage, and methods for improving wound healing and tissue repair, comprising administering the compositions of the present invention to an animal.
Claims25
A method of enhancing the delivery of exogenous 2′-deoxyadenosine to the tissue of an animal, comprising the step of administering to said animal of an acyl derivative of 2′-deoxyadenosine, having the formula
- wherein R1, R2 and R3 are the same or different and each of H or an acyl group derived from a carboxylic acid, provided that at least one of R1, R2 and R3 is not hydrogen.
A method of enhancing the delivery of exogenous 2′-deoxyguanosine to the tissue of an animal, comprising the step of administering to said animal an acyl derivative of 2′-deoxyguanosine having the formula
- wherein R1, R2 and R3 are the same or different and each is H or an acyl group derived from a carboxylic acid, provided that at least one of R1, R2 and R3 is not hydrogen.
A method of enhancing the delivery of exogenous 2′-deoxycytidine to the tissue of an animal, comprising the step of administering to said animal an acyl derivative of 2′-deoxycytidine, having the formula
- wherein R1, R2 and R3 are the same or different and each is H or an acyl group derived from a carboxylic acid, provided that at least one of R1, R2 and R3 is not hydrogen.
A method of enhancing the delivery of exogenous 2′-deoxythymidine to the tissue of an animal, comprising the step of administering to said animal an acyl derivative of 2′-deoxythymidine, having the formula
- wherein R1 is an acyl group derived from
- (a) an unbranched fatty acid with 2 to 15 or 17 to 22 carbon atoms,
- (b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine,
- (c) nicotinic acid, or
- (d) a dicarboxylic acid having 3 to 22 carbon atoms, or a pharmaceutically acceptable salt thereof.
A method of enhancing the delivery of exogenous 2′-deoxythymidine to the tissue of an animal, comprising the step of administering to said animal an acyl derivative of 2′-deoxythymidine, having the formula
- wherein R2 is an acyl group derived from
- (a) an unbranched fatty acid with 2 to 13 or 15 to 22 carbon atoms,
- (b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine,
- (c) nicotinic acid, or
- (d) a dicarboxylic acid with 3 to 22 carbon atoms, or a pharmaceutically acceptable salt thereof.
A method of enhancing the delivery of exogenous 2′-deoxythymidine to the tissue of an animal, comprising the step of administering to said animal an acyl derivative of 2′-deoxythymidine, having the formula
- wherein R1 and R2 are the same or different and each is an acyl group derived from
- (a) an unbranched fatty acid with 2 to 22 carbon atoms,
- (b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine,
- (c) nicotinic acid, or
- (d) a dicarboxylic acid with 3 to 22 carbon atoms, or a pharmaceutically acceptable salt thereof.
A method of enhancing the delivery of exogenous 2′-deoxythymidine to the tissue of an animal, comprising the step of administering to said animal an acyl derivative of 2′-deoxythymidine, having the formula
- wherein R1 and R2 are the same or different and each is an acyl group derived from
- (a) an unbranched fatty acid with 2 to 22 carbon atoms,
- (b) an amino acid selected from the group consisting of glycine, the L forms of alanine, valine, leucine, isoleucine, tyrosine, proline, hydroxyproline, serine, threonine, cysteine, aspartic acid, glutamic acid, arginine, lysine, histidine, carnitine, and ornithine,
- (c) nicotinic acid, or
- (d) a dicarboxylic acid with 3 to 22 carbon atoms, and R3 is an acyl group derived from an optionally substituted benzoyl or heterocyclic acid that is substantially nontoxic, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.