Methods and compositions for inducing tumor-specific cytotoxicity
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsAbraham Hochberg, Suhail Ayesh
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Abstract
The invention relates to the specific expression of heterologous sequences, particularly genes encoding cytotoxic products, in tumor cells under the control of regulatory transcriptional sequences. Particularly preferred promoters include H19 regulatory sequences, the IGF-1 promoter and the IGF-2 P3 and P4 promoters. The invention provides expression constructs and methods of administering such expression constructs. The compositions and methods of the invention are useful in the treatment of cancer.
Claims12
A method of treating cancer in a subject comprising administering, into a tumor of a subject, a polynucleotide encoding a cytotoxic gene product operably linked to a regulatory sequence, wherein the regulatory sequence is derived from an H19, IGF-1, or IGF-2 P4 promoter regulatory element.
Dependencies are inferred from the claim text.