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US 6,306,826 B1Granted
Treatment of heart failure with growth hormone
AssigneeThe Regents of the University of California
InventorsJohn Ross, Jr., Kenneth R. Chien
Life of this patent
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Abstract
Heart failure following myocardial infarction is treated by administration of an angiotensin II inhibitor for 8-12 weeks, followed by administration of a growth hormone for 1-3 weeks.
Claims20
A method for treating heart failure after myocardial infarction in a subject, comprising:
- a) administering an angiotensin II (AT1) receptor inhibitor daily in a dosage of about 12.5 mg/day to about 50 mg/day to said subject for an initial period beginning from about the time of myocardial infarction to about 10 to about 12 weeks;
- b) reducing administration of the angiotensin II (AT1) receptor inhibitor following the about 10 to about 12 week period;
- and
- c) administering growth hormone beginning after the reduction of AT1 receptor inhibitor.
1 more element
A method of treating heart failure in a subject following an ischemic event, comprising;
- a) administering an angiotensin II (AT1) receptor inhibitor daily in a dosage of about 12.5 mg/day to about 50 mg/day to said subject over a period beginning about the time of said ischemic event, and continuing for a period sufficient to substantially permit favorable left ventricular remodeling or limit unfavorable ventricular remodeling;
- b) decreasing the dosage of AT1 receptor inhibitor at a time approximately after said ventricular remodeling period;
- and
- c) administering a growth hormone to said subject at a time approximately after said ventricular remodeling period.
1 more element
Dependencies are inferred from the claim text.