Phosphopeptides and methods of treating bone diseases
AssigneeBig Bear Bio, Inc.
InventorsYoshinari Kumagai, Akira Otaka
Life of this patent
Estimating the term…
Abstract
Phosphopeptides which significantly reduce bone loss or weakening are provided by the invention. Also provided is a method for treating or preventing any condition associated with bone loss or weakening by administering the phosphopeptides by oral or injectable means.
Claims9
A polypeptide comprising monomer units selected from the group consisting of:
- a unit (a) selected from the group consisting of (I) and (I′) wherein (I) is selected from the group consisting of any naturally occurring amino acid and (I′) is an amino acid residue of the general structural formula:
- wherein R1 is selected from the group consisting of
- and
- a unit (b) comprising an amino acid residue of the general structural formula (II):
- wherein R2 is selected from the group consisting of
- wherein R3 is an alkyl containing 1 to 7 carbon atoms, (a) and (b) are not the same, (b) is present in an amount of at least 10% of the total number of units in the polypeptide and the polypeptide comprises from six to thirty monomer units.
A polypeptide comprising a unit (a) selected from the group consisting of (I) and (I′) wherein (I) is selected from the group consisting of any naturally occurring amino acid and (I′) is an amino acid residue of the general structural formula (I′)
- and a unit (b) comprising an amino acid residue of the general structural formula (II):
- wherein the polypeptide is comprised at least 6 monomer units and further wherein monomer unit (b) comprises at least 10% of the total number of units in the polypeptide of the polypeptide.
A pharmaceutical composition which composition comprises a carrier and an amount of an active ingredient comprising a polypeptide comprising monomer units selected from the group consisting of:
- a unit (a) selected from the group consisting of (I) and (I′) wherein (I) is selected from the group consisting of any naturally occurring amino acid and (I′) is an amino acid residue of the general structural formula:
- wherein R1 is selected from the group consisting of
- a unit (b) comprising an amino acid residue of the general structural formula (II):
- and R2 is selected from the group consisting of
- and wherein (b) is present in an amount of at least 10% of the total number of units in the polypeptide and the polypeptide comprises from six to thirty monomer units.
Dependencies are inferred from the claim text.