Mucoadhesive granules of carbomer suitable for oral administration of drugs
AssigneeReckitt Benckiser Healthcare (UK) Limited
InventorsPeter William Dettmar, Paul Andrew Dickson, Frank Chadwick Hampson, Ian Gordon Jollife, William Peers
Life of this patent
Estimating the term…
Abstract
Mucoadhesive granules comprising a) carbomer and/or a salt thereof; and b) an inert filler. The granules preferably further comprise a pharmaceutically active agent suitable for sustained release into the gastrointestinal tract or for targeted delivery to the gastrointestinal mucosa.
Claims8
A process for the preparation of mucoadhesive granules which comprises the steps of:
- (i) mixing a carbomer and/or a salt thereof with an inert filler to obtain a mixture;
- (ii) adding to the mixture, whilst blending, a granulating fluid to obtain granules;
- and (iii) drying said granules.
A process for the preparation of mucoadhesive granules which comprises the steps of:
- (i) mixing a carbomer and/or a salt thereof with an inert filler and optionally with a pharmaceutically active agent to obtain a mixture;
- (ii) adding to the mixture, whilst blending, a granulating fluid, which optionally contains the pharmaceutically active agent, to obtain granules;
- and (iii) drying said granules.
A process for the preparation of mucoadhesive granules, said process comprising the steps of:
- (i) mixing a carbomer salt or a combination of carbomer and a salt thereof with an inert filler to obtain a mixture;
- (ii) adding to the mixture a granulating fluid to obtain granules;
- and (iii) drying said granules, wherein a base or a basic salt is included either in step (i) or in step (ii).
A process for the preparation of mucoadhesive granules, said process comprising the steps of:
- (i) mixing a carbomer salt or a combination of a carbomer and a salt thereof with an inert filler and optionally with a pharmaceutically active agent to obtain a mixture;
- (ii) adding to the mixture a granulating fluid which optionally contains the pharmaceutically active agent, to obtain granules;
- and (iii) drying said granules;
- wherein a base or a basic salt is included either in step (i) or in step (ii).
A process for tile preparation of mucoadhesive granules which comprises tie steps of (i) mixing a carbomer and/or a salt thereof with an inert filler to obtain a mixture;
- (ii) adding to the mixture, whilst blending, a granulating fluid to obtain granules, without passing the fluid-containing mixture through a, screen;
- and (iii) optionally drying said granules.
A process for the preparation of mucoadhesive granules which comprises the steps of:
- (i) mixing a carbomer and/or a salt thereof with an inert filler and optionally with a pharmaceutically active agent to obtain a mixture;
- (ii) adding to the mixture, whilst blending, a granulating fluid, which optionally contains the pharmaceutically active agent, to obtain granules, without passing the fluid-containing mixture through a screen;
- and (iii) optionally drying said granules.
A process for the preparation of mucoadhesive granules, said process comprising the steps of:
- (i) mixing a carbomer salt or a combination of carbomer and a salt thereof with an inert filler to obtain a mixture;
- (ii) adding to the mixture a granulating fluid to obtain granules, without passing the fluid-containing mixture through a screen;
- and (iii) optionally drying said granules, wherein a base or a basic salt is included either in step (i) or in step (ii).
A process for the preparation of mucoadhesive granules said process comprising the steps of:
- (i) mixing a carbomer salt or a combination of a carbomer and a salt thereof with an inert filler and optionally with a pharmaceutically active agent to obtain a mixture;
- (ii) adding to the mixture a granulating fluid which optionally contains the pharmaceutically active agent, to obtain granules, without passing the fluid-containing mixture through a screen;
- and (iii) optionally drying said granules;
- wherein a base or a basic salt is included either in step (i) or in step (ii).
Dependencies are inferred from the claim text.