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US 6,306,655 B1Granted
Antisense inhibition of C/EBP alpha expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrett P. Monia, Madeline M. Butler, Jacqueline Wyatt
Life of this patent
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of C/EBP alpha. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C/EBP alpha. Methods of using these compounds for modulation of C/EBP alpha expression and for treatment of diseases associated with expression of C/EBP alpha are provided.
Claims13
An antisense compound up to 30 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 19, 20, 26, 27, 30, 33, 34, 35, 37, 38, 39, 40, 43, 44, 45, 49, 51, 52, 53, 54, 56, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 70, 71, 73, 78, 79, 80, 82, 83, 84, 85, 86, 87, 89, 92 or 94 which inhibits the expression of human or mouse C/EBP alpha.
Dependencies are inferred from the claim text.