Specific tolerance in transplantation
AssigneeThe General Hospital Corporation
InventorDavid H. Sachs
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Abstract
In general, the invention features, a method of inducing tolerance in a recipient mammal, e.g., a human, of a first species to a tissue obtained from a mammal, e.g., a swine, e.g., a miniature swine, of a second species, which tissue expresses an MHC antigen, including inserting DNA encoding an MHC antigen of the second species into a bone marrow hematopoietic stem cell from the recipient mammal, and allowing the MHC antigen encoding DNA to be expressed in the recipient.
Claims40
An isolated bone marrow hematopoietic stem cell from a recipient mammal of a first species, comprising a DNA encoding an MHC class II antigen of a second mammal species.
A human bone marrow hematopoietic stem cell, comprising a DNA encoding a swine SLA class II antigen.
A bone marrow hematopoietic stem cell from a recipient human into which has been inserted DNA encoding an MHC class II antigen of a MHC nonidentical donor of the same species.
A human bone marrow hematopoietic stem cell, said stem cell having inserted therein DNA encoding an MHC class II antigen from an MHC nonidentical donor of the same species.
A bone marrow hematopoietic stem cell from a recipient animal of a first species into which stem cell there is inserted DNA encoding an MHC class II antigen of a second animal species.
Dependencies are inferred from the claim text.