Nucleic acid molecule encoding a β-erythroid krüppel-like factor that binds to a δ-globin promoter
AssigneeThe UAB Research Foundation
InventorsTim M. Townes, David Donze
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Abstract
The invention features δ-erythroid krüppel-like factors (δ-EKLFs), and methods of using nucleic acids encoding δ-EKLFs to increase δ-globin gene expression in a cell.
Claims10
A nucleic acid molecule encoding a δ-EKLF polypeptide having the amino acid sequence of a β-EKLF polypeptide that comprises a substitution in amino acid position −1, 2, 3, 4, 5, or 6 of a zinc finger of said β-EKLF polypeptide, wherein said δ-EKLF polypeptide binds to a mammalian δ-globin promoter.
A cell that contains a nucleic acid molecule encoding a δ-EKLF polypeptide having the amino acid sequence of a β-EKLF polypeptide that comprises a substitution in amino acid position −1, 2, 3, 4, 5, or 6 of a zinc finger of said β-EKLF polypeptide, wherein said δ-EKLF polypeptide binds to a mammalian δ-globin promoter.
A vector containing a nucleic acid molecule encoding a δ-EKLF polypeptide having the amino acid sequence of a β-EKLF polypeptide that comprises a substitution in amino acid position −1, 2, 3, 4, 5, or 6 of a zinc finger of said β-EKLF polypeptide, wherein said δ-EKLF polypeptide binds to a mammalian δ-globin promoter.
Dependencies are inferred from the claim text.