Heterologous transcription factors
AssigneeARIAD Gene Therapeutics, Inc.
InventorsMichael Z. Gilman, Sridaran Natesan
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Abstract
This invention provides novel materials and methods involving the heterologous expression of transcription factors which are useful for effecting transcription of target genes in genetically engineered cells or organisms containing them. Target gene constructs and other materials useful for practicing the invention are also disclosed.
Claims2
A recombinant DNA sequence encoding a chimeric transcription factor comprising (a) one or more copies of a peptide sequence comprising all or part of a peptide sequence spanning positions 361 through 550 of human NF-κB p65, or a peptide sequence derived therefrom, and (b) a peptide sequence heterologous thereto and which is selected from a peptide sequence within the sequence of VP16 B, VP16 C, HSF, or CTF.
Dependencies are inferred from the claim text.